Function and Biology

Crystal structure of TNF-TNFR2 complex

Source organism: Homo sapiens
Biochemical function: tumor necrosis factor receptor binding
Biological process: immune response
Cellular component: membrane

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00020
Domain description: TNFR/NGFR cysteine-rich region
Occurring in:
  1. Tumor necrosis factor-binding protein 2
The deposited structure of PDB entry 3alq contains 18 copies of Pfam domain PF00020 (TNFR/NGFR cysteine-rich region) in Tumor necrosis factor-binding protein 2. Showing 3 copies in chain H [auth S].

PF00229
Domain description: TNF(Tumour Necrosis Factor) family
Occurring in:
  1. Tumor necrosis factor, soluble form
The deposited structure of PDB entry 3alq contains 6 copies of Pfam domain PF00229 (TNF(Tumour Necrosis Factor) family ) in Tumor necrosis factor, soluble form. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001368
Domain description: TNFR/NGFR cysteine-rich region
Occurring in:
  1. Tumor necrosis factor-binding protein 2
IPR006053
Domain description: Tumour necrosis factor
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR006052
Domain description: Tumour necrosis factor domain
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR002959
Domain description: Tumour necrosis factor alpha
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR008983
Domain description: Tumour necrosis factor-like domain superfamily
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR033996
Domain description: Tumor necrosis factor receptor 1B, N-terminal
Occurring in:
  1. Tumor necrosis factor-binding protein 2
IPR021184
Domain description: Tumour necrosis factor, conserved site
Occurring in:
  1. Tumor necrosis factor, soluble form

Structure domains

CATH CATH domains
2.10.50.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Tumor Necrosis Factor Receptor, subunit A; domain 2
Homology: Tumor Necrosis Factor Receptor, subunit A, domain 2
Occurring in:
  1. Tumor necrosis factor-binding protein 2
The deposited structure of PDB entry 3alq contains 12 copies of CATH domain 2.10.50.10 (Tumor Necrosis Factor Receptor, subunit A; domain 2) in Tumor necrosis factor-binding protein 2. Showing 2 copies in chain H [auth S].
2.60.120.40
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Tumor necrosis factor, soluble form
The deposited structure of PDB entry 3alq contains 6 copies of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor, soluble form. Showing 1 copy in chain A.