› 3au4

X-ray diffraction
1.9Å resolution

Structure of the human myosin-X MyTH4-FERM cassette bound to its specific cargo, DCC

Released:
DOI: 10.2210/pdb3au4/pdb
PDB entry 3au4 coloured by chain, front view.
PDB entry 3au4 coloured by chain, side view.
PDB entry 3au4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain.
Hirano Y, Hatano T, Takahashi A, Toriyama M, Inagaki N, Hakoshima T
EMBO J 30 2734-47 (2011)
PMID: 21642953

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154959 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Unconventional myosin-X Chain: A
Molecule details ›
Chain: A
Length: 555 amino acids
Theoretical weight: 63.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HD67 (Residues: 1486-2058; Coverage: 27%)
Gene names: KIAA0799, MYO10
Sequence domains:
Structure domains:
Netrin receptor DCC Chain: B
Molecule details ›
Chain: B
Length: 63 amino acids
Theoretical weight: 6.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43146 (Residues: 1390-1447; Coverage: 4%)
Gene names: DCC, IGDCC1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 85.221Å b: 49.564Å c: 93.978Å
α: 90° β: 116.71° γ: 90°
R-values:
R R work R free
0.215 0.215 0.233
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Myosin-X: a MyTH-FERM myosin at the tips of filopodia.
Kerber et al. (2011)
5 more

3 mentions without citation

Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain.
Hirano et al. (2011)
2 more