› 3b2t

X-ray diffraction
1.8Å resolution

Structure of phosphotransferase

Released:
DOI: 10.2210/pdb3b2t/pdb
PDB entry 3b2t coloured by chain, front view.
PDB entry 3b2t coloured by chain, side view.
PDB entry 3b2t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.
Lew ED, Bae JH, Rohmann E, Wollnik B, Schlessinger J
Proc Natl Acad Sci U S A 104 19802-7 (2007)
PMID: 18056630

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 311 amino acids
Theoretical weight: 35.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 458-768; Coverage: 39%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PO4 4 x PO4
Ligand M33 2 x M33
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21212
Unit cell:
a: 67.698Å b: 80.345Å c: 118.603Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.201 0.233
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The Fibroblast Growth Factor signaling pathway.
Ornitz et al. (2015)
8 more

6 mentions without citation

The role of protein structural analysis in the next generation sequencing era.
Yue et al. (2014)
5 more