› 3b7k

X-ray diffraction
2.7Å resolution

Human Acyl-coenzyme A thioesterase 12

Released:
DOI: 10.2210/pdb3b7k/pdb
PDB entry 3b7k coloured by chain, front view.
PDB entry 3b7k coloured by chain, side view.
PDB entry 3b7k coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lehtio L, Busam RD, Arrowsmith CH, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Hallberg BM, Herman MD, Johansson A, Johansson I, Kallas A, Karlberg T, Kotenyova T, Moche M, Nilsson ME, Nordlund P, Nyman T, Persson C, Sagemark J, Sundstrom M, Svensson L, Thorsell AG, Tresaugues L, Van Den Berg S, Weigelt J, Welin M, Berglund H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + H(2)O = CoA + acetate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl-coenzyme A thioesterase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 333 amino acids
Theoretical weight: 37.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WYK0 (Residues: 7-316; Coverage: 56%)
Gene names: ACOT12, CACH, CACH1, STARD15
Sequence domains: Thioesterase superfamily
Structure domains: Hotdog Thioesterase

Ligands and Environments


Cofactor: Ligand COA 3 x COA
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2221
Unit cell:
a: 82.7Å b: 126.05Å c: 185.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.285
Expression system: Escherichia coli

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