› 3bbt

X-ray diffraction
2.8Å resolution

crystal structure of the ErbB4 kinase in complex with lapatinib

Released:
DOI: 10.2210/pdb3bbt/pdb
PDB entry 3bbt coloured by chain, front view.
PDB entry 3bbt coloured by chain, side view.
PDB entry 3bbt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of activation and inhibition of the HER4/ErbB4 kinase.
Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ
Structure 16 460-7 (2008)
PMID: 18334220

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172255 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ERBB4 intracellular domain Chains: B, D
Molecule details ›
Chains: B, D
Length: 328 amino acids
Theoretical weight: 37.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15303 (Residues: 702-1029; Coverage: 26%)
Gene names: ERBB4, HER4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FMM 2 x FMM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P61
Unit cell:
a: 102.682Å b: 102.682Å c: 185.124Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.253 0.251 0.289
Expression system: Spodoptera frugiperda

Quick links

Citations

28 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
27 more

23 mentions without citation

Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism.
Abourehab et al. (2021)
22 more