› 3bhh

X-ray diffraction
2.4Å resolution

Crystal structure of human calcium/calmodulin-dependent protein kinase IIB isoform 1 (CAMK2B)

Released:
DOI: 10.2210/pdb3bhh/pdb
PDB entry 3bhh coloured by chain, front view.
PDB entry 3bhh coloured by chain, side view.
PDB entry 3bhh coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Rellos P, Niesen F, Burgess N, Bullock A, Berridge G, Pike ACW, Ugochukwu E, Pilka ES, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171752 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type II subunit beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 295 amino acids
Theoretical weight: 33.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13554 (Residues: 11-303; Coverage: 44%)
Gene names: CAM2, CAMK2, CAMK2B, CAMKB
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 5CP 2 x 5CP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 173.4Å b: 79.2Å c: 98.7Å
α: 90° β: 104.5° γ: 90°
R-values:
R R work R free
0.225 0.223 0.275
Expression system: Escherichia coli

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