› 3bj4

X-ray diffraction
2Å resolution

The KCNQ1 (Kv7.1) C-terminus, a multi-tiered scaffold for subunit assembly and protein interaction

Released:
DOI: 10.2210/pdb3bj4/pdb
PDB entry 3bj4 coloured by chain, front view.
PDB entry 3bj4 coloured by chain, side view.
PDB entry 3bj4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction.
Wiener R, Haitin Y, Shamgar L, Fernández-Alonso MC, Martos A, Chomsky-Hecht O, Rivas G, Attali B, Hirsch JA
J Biol Chem 283 5815-30 (2008)
PMID: 18165683

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156415 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily KQT member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 49 amino acids
Theoretical weight: 5.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51787 (Residues: 574-622; Coverage: 7%)
Gene names: KCNA8, KCNA9, KCNQ1, KVLQT1
Sequence domains: KCNQ voltage-gated potassium channel

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3121
Unit cell:
a: 51.321Å b: 51.321Å c: 71.094Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.221 0.255
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Ancillary subunits associated with voltage-dependent K+ channels.
Pongs et al. (2010)
23 more

8 mentions without citation

The Structure and Topology of α-Helical Coiled Coils.
Lupas et al. (2017)
7 more