› 3bkb

X-ray diffraction
1.78Å resolution

Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)

Released:
DOI: 10.2210/pdb3bkb/pdb
PDB entry 3bkb coloured by chain, front view.
PDB entry 3bkb coloured by chain, side view.
PDB entry 3bkb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S
Cell 134 793-803 (2008)
PMID: 18775312

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139506 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fes/Fps Chain: A
Molecule details ›
Chain: A
Length: 377 amino acids
Theoretical weight: 42.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07332 (Residues: 448-822; Coverage: 46%)
Gene names: FES, FPS
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand EDO 8 x EDO
Ligand STU 1 x STU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P63
Unit cell:
a: 80.404Å b: 80.404Å c: 131.411Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.15 0.148 0.189
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Protein kinases: evolution of dynamic regulatory proteins.
Taylor et al. (2011)
29 more

11 mentions without citation

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.
Shah et al. (2018)
10 more