› 3blj

X-ray diffraction
2.2Å resolution

Crystal structure of human poly(ADP-ribose) polymerase 15, catalytic fragment

Released:
DOI: 10.2210/pdb3blj/pdb
PDB entry 3blj coloured by chain, front view.
PDB entry 3blj coloured by chain, side view.
PDB entry 3blj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
Karlberg T, Klepsch M, Thorsell AG, Andersson CD, Linusson A, Schüler H
J Biol Chem 290 7336-44 (2015)
PMID: 25635049

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175095 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 25.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q460N3 (Residues: 481-678; Coverage: 29%)
Gene names: BAL3, PARP15
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain
Structure domains: Phosphoenolpyruvate Carboxykinase; domain 3

Ligands and Environments

3 bound ligands:
Ligand NA 2 x NA
Ligand CL 1 x CL
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P212121
Unit cell:
a: 45.21Å b: 68.12Å c: 158.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.179 0.243
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Translation inhibition and stress granules in the antiviral immune response.
McCormick et al. (2017)
19 more

4 mentions without citation

Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
Karlberg et al. (2015)
3 more