Function and Biology Details
Reaction catalysed:
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2)
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
DNA oxidative demethylase ALKBH2 and DNA (preferred)
PDBe Complex ID:
PDB-CPX-116110 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (3 distinct):
DNA oxidative demethylase ALKBH2
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 22.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: 2OG-Fe(II) oxygenase superfamily
Structure domains: Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Length: 202 amino acids
Theoretical weight: 22.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q6NS38 (Residues: 57-258; Coverage: 77%)
Sequence domains: 2OG-Fe(II) oxygenase superfamily
Structure domains: Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 19-BM
Spacegroup:
P41212
Expression systems:
- Escherichia coli BL21(DE3)
- Not provided
