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Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4

X-ray diffraction
2Å resolution
PDB entry 3bun coloured by chain, front view.
PDB entry 3bun coloured by chain, side view.
PDB entry 3bun coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Protein sprouty homolog 4
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Multimeric state: monomeric
Accessible surface area: 1137.12 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189877
Assembly 2
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Assembly Name: E3 ubiquitin-protein ligase CBL
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Multimeric state: monomeric
Accessible surface area: 14790.8 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149756
Assembly 3 (preferred)
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Assembly Name: E3 ubiquitin-protein ligase CBL and Protein sprouty homolog 4
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Multimeric state: hetero dimer
Accessible surface area: 14867.47 Å2
Buried surface area: 1060.46 Å2
Dissociation area: 530.23 Å2
Dissociation energy (ΔGdiss): 6.02 kcal/mol
Dissociation entropy (TΔSdiss): 6.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149768

Macromolecules

Protein sprouty homolog 4
Chain: A
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9C004 (Residues: 46-58; Coverage: 4%)
Gene name: SPRY4
Protein sprouty homolog 4 in PDB entry 3bun, assembly 3, front view.
Protein sprouty homolog 4 in PDB entry 3bun, assembly 3, side view.
Protein sprouty homolog 4 in PDB entry 3bun, assembly 3, top view.
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E3 ubiquitin-protein ligase CBL
Chain: B
Length: 329 amino acids
Theoretical weight: 38.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22681 (Residues: 23-351; Coverage: 36%)
Gene names: CBL, CBL2, RNF55
Pfam:
InterPro:
CATH:
SCOP:
E3 ubiquitin-protein ligase CBL in PDB entry 3bun, assembly 3, front view.
E3 ubiquitin-protein ligase CBL in PDB entry 3bun, assembly 3, side view.
E3 ubiquitin-protein ligase CBL in PDB entry 3bun, assembly 3, top view.
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