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Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4

Source organism: Homo sapiens
Biochemical function: calcium ion binding
Biological process: regulation of signaling
Cellular component: not assigned

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EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02762
Domain description: CBL proto-oncogene N-terminus, SH2-like domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
The deposited structure of PDB entry 3bun contains 1 copy of Pfam domain PF02762 (CBL proto-oncogene N-terminus, SH2-like domain) in E3 ubiquitin-protein ligase CBL. Showing 1 copy in chain B.

PF02761
Domain description: CBL proto-oncogene N-terminus, EF hand-like domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
The deposited structure of PDB entry 3bun contains 1 copy of Pfam domain PF02761 (CBL proto-oncogene N-terminus, EF hand-like domain) in E3 ubiquitin-protein ligase CBL. Showing 1 copy in chain B.

PF02262
Domain description: CBL proto-oncogene N-terminal domain 1
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
The deposited structure of PDB entry 3bun contains 1 copy of Pfam domain PF02262 (CBL proto-oncogene N-terminal domain 1) in E3 ubiquitin-protein ligase CBL. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR036860
Domain description: SH2 domain superfamily
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR014742
Domain description: Adaptor protein Cbl, SH2-like domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR036537
Domain description: Adaptor protein Cbl, N-terminal domain superfamily
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR014741
Domain description: Adaptor protein Cbl, EF hand-like
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR011992
Domain description: EF-hand domain pair
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR003153
Domain description: Adaptor protein Cbl, N-terminal helical
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR024159
Domain description: Adaptor protein Cbl, PTB domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR024162
Domain description: Adaptor protein Cbl
Occurring in:
  1. E3 ubiquitin-protein ligase CBL

Structure domains

CATH CATH domains
3.30.505.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SHC Adaptor Protein
Homology: SH2 domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
The deposited structure of PDB entry 3bun contains 1 copy of CATH domain 3.30.505.10 (SHC Adaptor Protein) in E3 ubiquitin-protein ligase CBL. Showing 1 copy in chain B.
1.10.238.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Recoverin; domain 1
Homology: EF-hand
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
The deposited structure of PDB entry 3bun contains 1 copy of CATH domain 1.10.238.10 (Recoverin; domain 1) in E3 ubiquitin-protein ligase CBL. Showing 1 copy in chain B.
1.20.930.20
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Transcription Elongation Factor S-II; Chain A
Homology: Adaptor protein Cbl, N-terminal domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
The deposited structure of PDB entry 3bun contains 1 copy of CATH domain 1.20.930.20 (Transcription Elongation Factor S-II; Chain A) in E3 ubiquitin-protein ligase CBL. Showing 1 copy in chain B.
SCOP SCOP annotations
55551
Class: Alpha and beta proteins (a+b)
Fold: SH2-like
Superfamily: SH2 domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
The deposited structure of PDB entry 3bun contains 1 copy of SCOP domain 55551 (SH2 domain) in E3 ubiquitin-protein ligase CBL. Showing 1 copy in chain B.
47547
Class: All alpha proteins
Fold: EF Hand-like
Superfamily: EF-hand
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
The deposited structure of PDB entry 3bun contains 1 copy of SCOP domain 47547 (EF-hand modules in multidomain proteins) in E3 ubiquitin-protein ligase CBL. Showing 1 copy in chain B.
47669
Class: All alpha proteins
Fold: N-cbl like
Superfamily: N-terminal domain of cbl (N-cbl)
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
The deposited structure of PDB entry 3bun contains 1 copy of SCOP domain 47669 (N-terminal domain of cbl (N-cbl)) in E3 ubiquitin-protein ligase CBL. Showing 1 copy in chain B.

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