› 3byb

X-ray diffraction
1.63Å resolution

Crystal structure of Textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom

Released:
DOI: 10.2210/pdb3byb/pdb
PDB entry 3byb coloured by chain, front view.
PDB entry 3byb coloured by chain, side view.
PDB entry 3byb coloured by chain, top view.
Source organism: Pseudonaja textilis textilis
Primary publication:
Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis).
Millers EK, Trabi M, Masci PP, Lavin MF, de Jersey J, Guddat LW
FEBS J 276 3163-75 (2009)
PMID: 19490116

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187467 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kunitz-type serine protease inhibitor textilinin-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 59 amino acids
Theoretical weight: 6.7 KDa
Source organism: Pseudonaja textilis textilis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q90WA1 (Residues: 25-83; Coverage: 100%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand ETX 2 x ETX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: I422
Unit cell:
a: 99.918Å b: 99.918Å c: 77.712Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.218
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Brown spider (Loxosceles genus) venom toxins: tools for biological purposes.
Chaim et al. (2011)
5 more

4 mentions without citation

Snake Venom Peptides: Tools of Biodiscovery.
Munawar et al. (2018)
3 more