› 3byv

X-ray diffraction
1.8Å resolution

Crystal structure of Toxoplasma gondii specific rhoptry antigen kinase domain

Released:
DOI: 10.2210/pdb3byv/pdb
PDB entry 3byv coloured by chain, front view.
PDB entry 3byv coloured by chain, side view.
PDB entry 3byv coloured by chain, top view.
Source organism: Toxoplasma gondii
Primary publication:
Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii.
Qiu W, Wernimont A, Tang K, Taylor S, Lunin V, Schapira M, Fentress S, Hui R, Sibley LD
EMBO J 28 969-79 (2009)
PMID: 19197235

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127543 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 377 amino acids
Theoretical weight: 43.77 KDa
Source organism: Toxoplasma gondii
Expression system: Escherichia coli
UniProt:
  • Canonical: O15693 (Residues: 210-568; Coverage: 67%)
Sequence domains: Kinase-like
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1, RIGAKU FR-E+ DW
Spacegroup: P212121
Unit cell:
a: 59.072Å b: 69.821Å c: 85.418Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.233
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Pseudokinases-remnants of evolution or key allosteric regulators?
Zeqiraj et al. (2010)
6 more

11 mentions without citation

Modulation of innate immunity by Toxoplasma gondii virulence effectors.
Hunter et al. (2012)
10 more