› 3c0i

X-ray diffraction
1.85Å resolution

CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form

Released:
DOI: 10.2210/pdb3c0i/pdb
PDB entry 3c0i coloured by chain, front view.
PDB entry 3c0i coloured by chain, side view.
PDB entry 3c0i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CASK Functions as a Mg2+-independent neurexin kinase.
Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC
Cell 133 328-39 (2008)
PMID: 18423203

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peripheral plasma membrane protein CASK Chain: A
Molecule details ›
Chain: A
Length: 351 amino acids
Theoretical weight: 39.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O14936 (Residues: 1-337; Coverage: 36%)
Gene names: CASK, LIN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 3AM 1 x 3AM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P212121
Unit cell:
a: 58.539Å b: 62.221Å c: 98.602Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.182 0.234
Expression system: Escherichia coli BL21

Quick links

Citations

51 review citations

The presynaptic active zone.
Südhof TC. (2012)
50 more

5 mentions without citation

Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC. (2008)
4 more