› 3caa

X-ray diffraction
2.4Å resolution

CLEAVED ANTICHYMOTRYPSIN A347R

Released:
DOI: 10.2210/pdb3caa/pdb
PDB entry 3caa coloured by chain, front view.
PDB entry 3caa coloured by chain, side view.
PDB entry 3caa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Lukacs CM, Rubin H, Christianson DW
Biochemistry 37 3297-304 (1998)
PMID: 9521649

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133792 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-1-antichymotrypsin His-Pro-less Chain: A
Molecule details ›
Chain: A
Length: 341 amino acids
Theoretical weight: 38.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01011 (Residues: 43-383; Coverage: 85%)
Gene names: AACT, GIG24, GIG25, SERPINA3
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Alpha-1-antichymotrypsin His-Pro-less Chain: B
Molecule details ›
Chain: B
Length: 37 amino acids
Theoretical weight: 4.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01011 (Residues: 387-423; Coverage: 9%)
Gene names: AACT, GIG24, GIG25, SERPINA3

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P212121
Unit cell:
a: 74.12Å b: 77.73Å c: 79.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.28
Expression system: Escherichia coli

Quick links

Citations

2 review citations

New approaches to rational drug design.
Farber GK. (1999)
1 more

1 mention without citation

Propedia: a database for protein-peptide identification based on a hybrid clustering algorithm.
Martins et al. (2021)