› 3cft

X-ray diffraction
1.87Å resolution

Crystal structure of human transthyretin in complex with 1-amino-5-naphthalene sulfonate

Released:
DOI: 10.2210/pdb3cft/pdb
PDB entry 3cft coloured by chain, front view.
PDB entry 3cft coloured by chain, side view.
PDB entry 3cft coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of a novel ligand binding motif in the transthyretin channel.
Lima LM, Silva Vde A, Palmieri Lde C, Oliveira MC, Foguel D, Polikarpov I
Bioorg Med Chem 18 100-10 (2010)
PMID: 19954984

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 12.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 30-147; Coverage: 93%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand 5NS 3 x 5NS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: P21212
Unit cell:
a: 42.96Å b: 85.61Å c: 63.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.239
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds.
Issa et al. (2011)
12 other articles

1 mention without citation

An anti-hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop.
Fanning et al. (2011)