› 3d0n

X-ray diffraction
1.55Å resolution

Crystal structure of human carbonic anhydrase XIII

Released:
DOI: 10.2210/pdb3d0n/pdb
PDB entry 3d0n coloured by chain, front view.
PDB entry 3d0n coloured by chain, side view.
PDB entry 3d0n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.
Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G
Proteins 74 164-75 (2009)
PMID: 18618712

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 264 amino acids
Theoretical weight: 29.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N1Q1 (Residues: 1-262; Coverage: 100%)
Gene name: CA13
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand ACT 2 x ACT
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21
Unit cell:
a: 57.78Å b: 58.21Å c: 72.12Å
α: 90° β: 92.36° γ: 90°
R-values:
R R work R free
0.168 0.168 0.188
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Structure-based drug discovery of carbonic anhydrase inhibitors.
Supuran CT. (2012)
11 more

3 mentions without citation

Crystallography and Its Impact on Carbonic Anhydrase Research.
Lomelino et al. (2018)
2 more