› 3d24

X-ray diffraction
2.11Å resolution

Crystal structure of ligand-binding domain of estrogen-related receptor alpha (ERRalpha) in complex with the peroxisome proliferators-activated receptor coactivator-1alpha box3 peptide (PGC-1alpha)

Released:
DOI: 10.2210/pdb3d24/pdb
PDB entry 3d24 coloured by chain, front view.
PDB entry 3d24 coloured by chain, side view.
PDB entry 3d24 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop.
Greschik H, Althage M, Flaig R, Sato Y, Chavant V, Peluso-Iltis C, Choulier L, Cronet P, Rochel N, Schüle R, Strömstedt PE, Moras D
J Biol Chem 283 20220-30 (2008)
PMID: 18441008

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145850 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Steroid hormone receptor ERR1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 253 amino acids
Theoretical weight: 27.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11474 (Residues: 192-423; Coverage: 55%)
Gene names: ERR1, ESRL1, ESRRA, NR3B1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Chains: B, D
Molecule details ›
Chains: B, D
Length: 22 amino acids
Theoretical weight: 2.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UBK2 (Residues: 198-219; Coverage: 3%)
Gene names: LEM6, PGC1, PGC1A, PPARGC1, PPARGC1A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 119.4Å b: 56Å c: 96.2Å
α: 90° β: 106.4° γ: 90°
R-values:
R R work R free
0.212 0.212 0.255
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

4 review citations

Structural and functional insights into nuclear receptor signaling.
Jin et al. (2010)
3 more

9 mentions without citation

NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding.
Khalturin et al. (2018)
8 more