› 3d6r

X-ray diffraction
2Å resolution

Structure of an avian influenza A virus NS1 protein effector domain

Released:
DOI: 10.2210/pdb3d6r/pdb
PDB entry 3d6r coloured by chain, front view.
PDB entry 3d6r coloured by chain, side view.
PDB entry 3d6r coloured by chain, top view.
Source organism: Influenza A virus (A/duck/Alberta/60/1976(H12N5))
Primary publication:
Structure of an avian influenza A virus NS1 protein effector domain.
Hale BG, Barclay WS, Randall RE, Russell RJ
Virology 378 1-5 (2008)
PMID: 18585749

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159565 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-structural protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 158 amino acids
Theoretical weight: 17.75 KDa
Source organism: Influenza A virus (A/duck/Alberta/60/1976(H12N5))
Expression system: Escherichia coli
UniProt:
  • Canonical: P69270 (Residues: 73-230; Coverage: 69%)
Gene name: NS
Sequence domains: Influenza non-structural protein (NS1)
Structure domains: Influenza virus non-structural protein, effector domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P6522
Unit cell:
a: 65.249Å b: 65.249Å c: 338.767Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.183 0.224
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Innate immune evasion strategies of influenza viruses.
Hale et al. (2010)
10 more

8 mentions without citation

A transient homotypic interaction model for the influenza A virus NS1 protein effector domain.
Kerry et al. (2011)
7 more