› 3d9s

X-ray diffraction
2Å resolution

Human Aquaporin 5 (AQP5) - High Resolution X-ray Structure

Released:
DOI: 10.2210/pdb3d9s/pdb
PDB entry 3d9s coloured by chain, front view.
PDB entry 3d9s coloured by chain, side view.
PDB entry 3d9s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution x-ray structure of human aquaporin 5.
Horsefield R, Nordén K, Fellert M, Backmark A, Törnroth-Horsefield S, Terwisscha van Scheltinga AC, Kvassman J, Kjellbom P, Johanson U, Neutze R
Proc Natl Acad Sci U S A 105 13327-32 (2008)
PMID: 18768791

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aquaporin-5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 266 amino acids
Theoretical weight: 28.4 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P55064 (Residues: 2-265; Coverage: 100%)
Gene name: AQP5
Sequence domains: Major intrinsic protein
Structure domains: Glycerol uptake facilitator protein.

Ligands and Environments

1 bound ligand:
Ligand PS6 1 x PS6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P212121
Unit cell:
a: 90.477Å b: 90.644Å c: 184.395Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.162 0.193
Expression system: Komagataella pastoris

Quick links

Citations

37 review citations

Human aquaporins: regulators of transcellular water flow.
Day et al. (2014)
36 more

48 mentions without citation

Aquaporins: important but elusive drug targets.
Verkman et al. (2014)
47 more