› 3dad

X-ray diffraction
2.3Å resolution

Crystal structure of the N-terminal regulatory domains of the formin FHOD1

Released:
DOI: 10.2210/pdb3dad/pdb
PDB entry 3dad coloured by chain, front view.
PDB entry 3dad coloured by chain, side view.
PDB entry 3dad coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.
Schulte A, Stolp B, Schönichen A, Pylypenko O, Rak A, Fackler OT, Geyer M
Structure 16 1313-23 (2008)
PMID: 18786395

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195325 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FH1/FH2 domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y613 (Residues: 1-339; Coverage: 29%)
Gene names: FHOD1, FHOS, FHOS1
Sequence domains: Formin N-terminal GTPase-binding domain
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 35.444Å b: 73.931Å c: 78.674Å
α: 78.24° β: 86.17° γ: 89.67°
R-values:
R R work R free
0.219 0.219 0.259
Expression system: Escherichia coli

Quick links

Citations

10 review citations

A nucleator arms race: cellular control of actin assembly.
Campellone et al. (2010)
9 more

7 mentions without citation

An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling.
Patel et al. (2010)
6 more