› 3dju

X-ray diffraction
2.26Å resolution

Crystal structure of human BTG2

Released:
DOI: 10.2210/pdb3dju/pdb
PDB entry 3dju coloured by chain, front view.
PDB entry 3dju coloured by chain, side view.
PDB entry 3dju coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity.
Yang X, Morita M, Wang H, Suzuki T, Yang W, Luo Y, Zhao C, Yu Y, Bartlam M, Yamamoto T, Rao Z
Nucleic Acids Res 36 6872-81 (2008)
PMID: 18974182

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160281 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein BTG2 Chain: B
Molecule details ›
Chain: B
Length: 122 amino acids
Theoretical weight: 13.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78543 (Residues: 7-128; Coverage: 77%)
Gene names: BTG2, PC3
Sequence domains: BTG family
Structure domains: Anti-proliferative protein, N-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P212121
Unit cell:
a: 39.272Å b: 40.751Å c: 67.971Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.194 0.263
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The mammalian anti-proliferative BTG/Tob protein family.
Winkler GS. (2010)
8 more

6 mentions without citation

Structure and function of molecular machines involved in deadenylation-dependent 5'-3' mRNA degradation.
Zhao et al. (2023)
5 more