› 3dk3

X-ray diffraction
2.02Å resolution

Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

Released:
DOI: 10.2210/pdb3dk3/pdb
PDB entry 3dk3 coloured by chain, front view.
PDB entry 3dk3 coloured by chain, side view.
PDB entry 3dk3 coloured by chain, top view.
Source organism: Mus musculus
Entry author: Lewis HA

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 293 amino acids
Theoretical weight: 33.94 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00520 (Residues: 233-514; Coverage: 25%)
Gene names: Abl, Abl1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SX7 2 x SX7
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21212
Unit cell:
a: 106.254Å b: 131.806Å c: 56.229Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.248
Expression system: Escherichia coli

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