› 3dkg

X-ray diffraction
1.91Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 35.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08581 (Residues: 1049-1360; Coverage: 23%)
Gene name: MET
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand SX8 1 x SX8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 42.972Å b: 46.452Å c: 159.236Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.238
Expression system: Spodoptera frugiperda

Quick links

Citations

20 review citations

Targeting MET in cancer: rationale and progress.
Gherardi et al. (2012)
19 more

1 mention without citation

Data driven polypharmacological drug design for lung cancer: analyses for targeting ALK, MET, and EGFR.
Narayanan et al. (2017)