3dnn

Electron Microscopy
20Å resolution

Molecular structure for the HIV-1 gp120 trimer in the unliganded state

Released:
Source organism: HIV-1 M:B_HXB2R
Primary publication:
Molecular architecture of native HIV-1 gp120 trimers.
Nature 455 109-13 (2008)
PMID: 18668044
Related structures: EMD-5019

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
PDBe Complex ID:
PDB-CPX-137978 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Surface protein gp120 Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 35 amino acids
Theoretical weight: 4.23 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Homo sapiens
UniProt:
  • Canonical: P04578 (Residues: 90-124; Coverage: 4%)
Gene name: env
Surface protein gp120 Chains: B, E, H
Molecule details ›
Chains: B, E, H
Length: 170 amino acids
Theoretical weight: 18.57 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Homo sapiens
UniProt:
  • Canonical: P04578 (Residues: 198-297, 330-396; Coverage: 20%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Surface protein gp120 Chains: C, F, I
Molecule details ›
Chains: C, F, I
Length: 83 amino acids
Theoretical weight: 9.33 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Homo sapiens
UniProt:
  • Canonical: P04578 (Residues: 410-492; Coverage: 10%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 20Å
Relevant EMDB volumes: EMD-5019
Expression system: Homo sapiens