› 3dp6

X-ray diffraction
1.55Å resolution

Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate

Released:
DOI: 10.2210/pdb3dp6/pdb
PDB entry 3dp6 coloured by chain, front view.
PDB entry 3dp6 coloured by chain, side view.
PDB entry 3dp6 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of the S1S2 glutamate binding domain of GLuR3.
Ahmed AH, Wang Q, Sondermann H, Oswald RE
Proteins 75 628-37 (2009)
PMID: 19003990

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 279 amino acids
Theoretical weight: 30.81 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-794; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand ZN 6 x ZN
Ligand GLU 3 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21212
Unit cell:
a: 113.84Å b: 163.184Å c: 47.324Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.244
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Functional insights from glutamate receptor ion channel structures.
Kumar et al. (2013)
4 more

11 mentions without citation

Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.
Ahmed et al. (2010)
10 more