› 3dtc

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 9 Chain: A
Molecule details ›
Chain: A
Length: 271 amino acids
Theoretical weight: 30.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P80192 (Residues: 136-406; Coverage: 25%)
Gene names: MAP3K9, MLK1, PRKE1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand VIN 1 x VIN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: P21212
Unit cell:
a: 56.93Å b: 126.304Å c: 41.359Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.218 0.282
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Targeting protein kinases in central nervous system disorders.
Chico et al. (2009)
8 more

18 mentions without citation

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.
Stark et al. (2011)
17 more