Function and Biology Details
Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Protein phosphatase 2A regulatory subunit PR55
- HEAT, type 2
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- WD40 repeat
- Metallo-dependent phosphatase-like
- Protein phosphatase 2A regulatory subunit PR55, conserved site
- Calcineurin-like phosphoesterase domain, ApaH type
- Serine/Threonine protein phosphatase PP2A-like
5 more domains
Structure domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-151654 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Molecule details ›
Chains: A, D
Length: 582 amino acids
Theoretical weight: 64.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: HEAT repeat
Structure domains: Leucine-rich Repeat Variant
Length: 582 amino acids
Theoretical weight: 64.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P30153 (Residues: 9-589; Coverage: 99%)
Sequence domains: HEAT repeat
Structure domains: Leucine-rich Repeat Variant
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Molecule details ›
Chains: B, E
Length: 447 amino acids
Theoretical weight: 51.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Length: 447 amino acids
Theoretical weight: 51.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P63151 (Residues: 1-447; Coverage: 100%)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Molecule details ›
Chains: C, F
Length: 309 amino acids
Theoretical weight: 35.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
Length: 309 amino acids
Theoretical weight: 35.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P67775 (Residues: 1-309; Coverage: 100%)
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
