› 3dyd

X-ray diffraction
2.3Å resolution

Human Tyrosine Aminotransferase

Released:
DOI: 10.2210/pdb3dyd/pdb
PDB entry 3dyd coloured by chain, front view.
PDB entry 3dyd coloured by chain, side view.
PDB entry 3dyd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Karlberg T, Moche M, Andersson J, Arrowsmith CH, Berglund H, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Kotenyova T, Lehtio L, Nilsson ME, Nordlund P, Nyman T, Olesen K, Persson C, Sagemark J, Thorsell AG, Tresaugues L, Van Den Berg S, Weigelt J, Welin M, Wikstrom M, Wisniewska M, Schuler H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148151 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 427 amino acids
Theoretical weight: 47.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17735 (Residues: 41-444; Coverage: 89%)
Gene name: TAT
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments


Cofactor: Ligand PLP 2 x PLP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 154.42Å b: 91.59Å c: 75.57Å
α: 90° β: 106.18° γ: 90°
R-values:
R R work R free
0.222 0.219 0.261
Expression system: Escherichia coli

Quick links