3e88

X-ray diffraction
2.5Å resolution

Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors

Released:
Source organism: Homo sapiens

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-152088 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
RAC-beta serine/threonine-protein kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 39.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P31751 (Residues: 146-480; Coverage: 70%)
Gene name: AKT2
Sequence domains:
Structure domains:
Glycogen synthase kinase-3 beta Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.12 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P49841 (Residues: 3-12; Coverage: 2%)
Gene name: GSK3B

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P32
Unit cell:
a: 116.885Å b: 116.885Å c: 45.115Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.23 0.273
Expression systems:
  • Spodoptera frugiperda
  • Not provided