› 3eb4

X-ray diffraction
2Å resolution

Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone

Released:
DOI: 10.2210/pdb3eb4/pdb
PDB entry 3eb4 coloured by chain, front view.
PDB entry 3eb4 coloured by chain, side view.
PDB entry 3eb4 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Cortisone dissociates the Shaker family K+ channels from their beta subunits.
Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle RC, Zhou M
Nat Chem Biol 4 708-14 (2008)
PMID: 18806782

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-gated potassium channel subunit beta-2 Chain: A
Molecule details ›
Chain: A
Length: 327 amino acids
Theoretical weight: 36.62 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P62483 (Residues: 35-361; Coverage: 89%)
Gene names: Ckbeta2, Kcnab2, Kcnb3
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments

2 bound ligands:
Ligand NDP 1 x NDP
Ligand PDN 1 x PDN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: I422
Unit cell:
a: 113.26Å b: 113.26Å c: 147.266Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.256
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Biochemical and physiological properties of K+ channel-associated AKR6A (KvĪ²) proteins.
Raph et al. (2019)
14 other articles

2 mentions without citation

Microbial alginate production, modification and its applications.
Hay et al. (2013)
1 more