3ehu

X-ray diffraction
1.96Å resolution

Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-139255 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Corticotropin-releasing factor receptor 1; Maltose/maltodextrin-binding periplasmic protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 476 amino acids
Theoretical weight: 52.61 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 25-392; Coverage: 99%)
  • Canonical: P34998 (Residues: 24-119; Coverage: 23%)
Gene names: CRFR, CRFR1, CRHR, CRHR1, JW3994, b4034, malE
Sequence domains:
Structure domains:
Corticoliberin Chains: C, D
Molecule details ›
Chains: C, D
Length: 21 amino acids
Theoretical weight: 2.31 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06850 (Residues: 175-194; Coverage: 12%)
Gene name: CRH
Sequence domains: Corticotropin-releasing factor family

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P1
Unit cell:
a: 49.203Å b: 63.48Å c: 85.875Å
α: 99.75° β: 106.28° γ: 101.67°
R-values:
R R work R free
0.212 0.209 0.256
Expression systems:
  • Escherichia coli
  • Not provided