› 3el7

X-ray diffraction
2.8Å resolution

Crystal structure of c-Src in complex with pyrazolopyrimidine 3

Released:
DOI: 10.2210/pdb3el7/pdb
PDB entry 3el7 coloured by chain, front view.
PDB entry 3el7 coloured by chain, side view.
PDB entry 3el7 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Small molecule recognition of c-Src via the Imatinib-binding conformation.
Dar AC, Lopez MS, Shokat KM
Chem Biol 15 1015-22 (2008)
PMID: 18940662

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PD3 1 x PD3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 42.36Å b: 63.13Å c: 56.05Å
α: 90° β: 91.9° γ: 90°
R-values:
R R work R free
0.22 0.22 0.288
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling.
Dar et al. (2011)
7 more

5 mentions without citation

Three-Dimensional Interactions Analysis of the Anticancer Target c-Src Kinase with Its Inhibitors.
Jha et al. (2020)
4 more