› 3eov

X-ray diffraction
2.6Å resolution

Crystal structure of cyclophilin from Leishmania donovani ligated with cyclosporin A

Released:
DOI: 10.2210/pdb3eov/pdb
PDB entry 3eov coloured by chain, front view.
PDB entry 3eov coloured by chain, side view.
PDB entry 3eov coloured by chain, top view.
Source organisms:
Primary publication:
Structure of cyclophilin from Leishmania donovani bound to cyclosporin at 2.6 A resolution: correlation between structure and thermodynamic data.
Venugopal V, Datta AK, Bhattacharyya D, Dasgupta D, Banerjee R
Acta Crystallogr D Biol Crystallogr 65 1187-95 (2009)
PMID: 19923714

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163515 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 172 amino acids
Theoretical weight: 19.09 KDa
Source organism: Leishmania donovani
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9U9R3 (Residues: 22-187; Coverage: 100%)
Gene name: CYP
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
CYCLOSPORIN A Chains: C, D
Molecule details ›
Chains: C, D
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DAL 2 x DAL
Ligand MLE 8 x MLE
Ligand MVA 2 x MVA
Ligand BMT 2 x BMT
Ligand ABA 2 x ABA
Ligand SAR 2 x SAR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 69.81Å b: 83.125Å c: 73.58Å
α: 90° β: 103.03° γ: 90°
R-values:
R R work R free
0.207 0.207 0.251
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Redox-assisted protein folding systems in eukaryotic parasites.
Haque et al. (2012)
3 other articles

7 mentions without citation

Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology.
da Trindade et al. (2018)
6 more