› 3esf

X-ray diffraction
2.01Å resolution

Crystal Structure of the enzyme Fe-superoxide dismutase TbSODB2 from Trypanosoma brucei

Released:
DOI: 10.2210/pdb3esf/pdb
PDB entry 3esf coloured by chain, front view.
PDB entry 3esf coloured by chain, side view.
PDB entry 3esf coloured by chain, top view.
Source organism: Trypanosoma brucei
Primary publication:
Systematic structural studies of iron superoxide dismutases from human parasites and a statistical coupling analysis of metal binding specificity.
Bachega JF, Navarro MV, Bleicher L, Bortoleto-Bugs RK, Dive D, Hoffmann P, Viscogliosi E, Garratt RC
Proteins 77 26-37 (2009)
PMID: 19384994

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173695 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 197 amino acids
Theoretical weight: 22.15 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2KN30 (Residues: 1-197; Coverage: 95%)
Gene name: sodb2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand FE 4 x FE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 68.302Å b: 76.504Å c: 76.981Å
α: 90° β: 92.7° γ: 90°
R-values:
R R work R free
0.177 0.175 0.219
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Superoxide dismutases and superoxide reductases.
Sheng et al. (2014)
4 more

3 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
2 more