› 3eyb

X-ray diffraction
2.79Å resolution

Structural and functional insights into the ligand binding domain of a non-duplicated RXR from the invertebrate chordate amphioxus

Released:
DOI: 10.2210/pdb3eyb/pdb
PDB entry 3eyb coloured by chain, front view.
PDB entry 3eyb coloured by chain, side view.
PDB entry 3eyb coloured by chain, top view.
Source organism: Branchiostoma floridae
Primary publication:
Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus.
Tocchini-Valentini GD, Rochel N, Escriva H, Germain P, Peluso-Iltis C, Paris M, Sanglier-Cianferani S, Van Dorsselaer A, Moras D, Laudet V
J Biol Chem 284 1938-48 (2009)
PMID: 18986992

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185338 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear hormone receptor RXR Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 219 amino acids
Theoretical weight: 24.7 KDa
Source organism: Branchiostoma floridae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8MX78 (Residues: 266-484; Coverage: 42%)
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 78.723Å b: 96.12Å c: 131.343Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 0.257
Expression system: Escherichia coli

Quick links

Citations

9 review citations

From carrot to clinic: an overview of the retinoic acid signaling pathway.
Theodosiou et al. (2010)
8 more

1 mention without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)