› 3faa

X-ray diffraction
3.35Å resolution

Crystal structure of TGFbRI complexed with a 2-aminoimidazole inhibitor

Released:
DOI: 10.2210/pdb3faa/pdb
PDB entry 3faa coloured by chain, front view.
PDB entry 3faa coloured by chain, side view.
PDB entry 3faa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
2-Aminoimidazoles inhibitors of TGF-beta receptor 1.
Bonafoux D, Chuaqui C, Boriack-Sjodin PA, Fitch C, Hankins G, Josiah S, Black C, Hetu G, Ling L, Lee WC
Bioorg Med Chem Lett 19 912-6 (2009)
PMID: 19135364

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 342 amino acids
Theoretical weight: 38.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36897 (Residues: 162-503; Coverage: 73%)
Gene names: ALK5, SKR4, TGFBR1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 55F 5 x 55F
Ligand PO4 13 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2221
Unit cell:
a: 174.861Å b: 248.852Å c: 138.628Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.271
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Structural biology of the TGFβ family.
Goebel et al. (2019)
6 other articles

9 mentions without citation

The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-β Signaling Pathway.
Liu et al. (2021)
8 more