› 3fby

X-ray diffraction
3.15Å resolution

The crystal structure of the signature domain of cartilage oligomeric matrix protein.

Released:
DOI: 10.2210/pdb3fby/pdb
PDB entry 3fby coloured by chain, front view.
PDB entry 3fby coloured by chain, side view.
PDB entry 3fby coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding.
Tan K, Duquette M, Joachimiak A, Lawler J
FASEB J 23 2490-501 (2009)
PMID: 19276170

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156003 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Cartilage oligomeric matrix protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 551 amino acids
Theoretical weight: 61.29 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: P49747 (Residues: 225-757; Coverage: 72%)
Gene name: COMP
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
2 bound ligands:
Ligand CA 88 x CA
Ligand SO4 10 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 192.242Å b: 192.242Å c: 145.681Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.202 0.266
Expression system: Drosophila

Quick links

Citations

5 review citations

Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: interaction, regulation and role in chondrogenesis.
Acharya et al. (2014)
4 more

13 mentions without citation

The thrombospondins.
Adams et al. (2011)
12 more