› 3fe4

X-ray diffraction
1.9Å resolution

Crystal Structure of Human Carbonic Anhydrase vi

Released:
DOI: 10.2210/pdb3fe4/pdb
PDB entry 3fe4 coloured by chain, front view.
PDB entry 3fe4 coloured by chain, side view.
PDB entry 3fe4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.
Pilka ES, Kochan G, Oppermann U, Yue WW
Biochem Biophys Res Commun 419 485-9 (2012)
PMID: 22366092

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149920 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 278 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23280 (Residues: 20-290; Coverage: 93%)
Gene name: CA6
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 51.65Å b: 80.048Å c: 133.441Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.235
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.
Supuran et al. (2018)
11 more

10 mentions without citation

Crystallography and Its Impact on Carbonic Anhydrase Research.
Lomelino et al. (2018)
9 more