› 3fib

X-ray diffraction
2.1Å resolution

RECOMBINANT HUMAN GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT (RESIDUES 143-411) BOUND TO CALCIUM AT PH 6.0: A FURTHER REFINEMENT OF PDB ENTRY 1FIB, AND DIFFERS FROM 1FIB BY THE MODELLING OF A CIS PEPTIDE BOND BETWEEN RESIDUES K338 AND C339

Released:
DOI: 10.2210/pdb3fib/pdb
PDB entry 3fib coloured by chain, front view.
PDB entry 3fib coloured by chain, side view.
PDB entry 3fib coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro.
Pratt KP, Côté HC, Chung DW, Stenkamp RE, Davie EW
Proc Natl Acad Sci U S A 94 7176-81 (1997)
PMID: 9207064

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrinogen gamma chain Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 28.26 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02679 (Residues: 170-418; Coverage: 58%)
Gene names: FGG, PRO2061
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 37.53Å b: 68.42Å c: 47.67Å
α: 90° β: 105.36° γ: 90°
R-values:
R R work R free
0.154 0.154 0.206
Expression system: Komagataella pastoris

Quick links

Citations

13 review citations

Fibrinogen and fibrin structure and functions.
Mosesson MW. (2005)
12 more

8 mentions without citation

The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro.
Pratt et al. (1997)
7 more