Function and Biology Details
Reaction catalysed:
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108247 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Botulinum neurotoxin F light chain
Molecule details ›
Chain: A
Length: 427 amino acids
Theoretical weight: 48.75 KDa
Source organism: Clostridium botulinum
Expression system: Escherichia coli
UniProt:
Sequence domains: Clostridial neurotoxin zinc protease
Structure domains: Metalloproteases ("zincins"), catalytic domain like
Length: 427 amino acids
Theoretical weight: 48.75 KDa
Source organism: Clostridium botulinum
Expression system: Escherichia coli
UniProt:
- Canonical:
A7GBG3 (Residues: 1-419; Coverage: 33%)
Sequence domains: Clostridial neurotoxin zinc protease
Structure domains: Metalloproteases ("zincins"), catalytic domain like
Vesicle-associated membrane protein 2
Molecule details ›
Chain: B
Length: 33 amino acids
Theoretical weight: 3.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Synaptobrevin
Length: 33 amino acids
Theoretical weight: 3.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P63027 (Residues: 27-57; Coverage: 27%)
Sequence domains: Synaptobrevin
