› 3fnv

X-ray diffraction
2.1Å resolution

Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2

Released:
DOI: 10.2210/pdb3fnv/pdb
PDB entry 3fnv coloured by chain, front view.
PDB entry 3fnv coloured by chain, side view.
PDB entry 3fnv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2.
Conlan AR, Axelrod HL, Cohen AE, Abresch EC, Zuris J, Yee D, Nechushtai R, Jennings PA, Paddock ML
J Mol Biol 392 143-53 (2009)
PMID: 19580816

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CDGSH iron-sulfur domain-containing protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 83 amino acids
Theoretical weight: 9.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N5K1 (Residues: 57-135; Coverage: 59%)
Gene names: CDGSH2, CISD2, ERIS, ZCD2
Sequence domains: Iron-binding zinc finger CDGSH type
Structure domains: CDGSH iron-sulfur domain, mitoNEET-type

Ligands and Environments

1 bound ligand:
Ligand FES 2 x FES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 40.904Å b: 48.579Å c: 74.104Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.216
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Iron-sulfur proteins in health and disease.
Sheftel et al. (2010)
19 more

10 mentions without citation

An Updated Overview on the Role of Small Molecules and Natural Compounds in the "Young Science" of Rejuvenation.
Ribaudo et al. (2023)
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