› 3fx0

X-ray diffraction
3.2Å resolution

Crystal structure of Human NEMO CC2_LZ domain

Released:
DOI: 10.2210/pdb3fx0/pdb
PDB entry 3fx0 coloured by chain, front view.
PDB entry 3fx0 coloured by chain, side view.
PDB entry 3fx0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for recognition of diubiquitins by NEMO.
Lo YC, Lin SC, Rospigliosi CC, Conze DB, Wu CJ, Ashwell JD, Eliezer D, Wu H
Mol Cell 33 602-15 (2009)
PMID: 19185524

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NF-kappa-B essential modulator Chains: A, B
Molecule details ›
Chains: A, B
Length: 96 amino acids
Theoretical weight: 11.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6K9 (Residues: 246-337; Coverage: 22%)
Gene names: FIP3, IKBKG, NEMO
Sequence domains: Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
Structure domains: Nemo cc2-lz domain - 1d5 darpin complex

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P65
Unit cell:
a: 76.194Å b: 76.194Å c: 76.892Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.247 0.306
Expression system: Escherichia coli

Quick links

Citations

73 review citations

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Kawai et al. (2010)
72 more

8 mentions without citation

Structural basis for recognition of diubiquitins by NEMO.
Lo et al. (2009)
7 more