› 3fxk

X-ray diffraction
2.1Å resolution

Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 10 mM of Mn2+

Released:
DOI: 10.2210/pdb3fxk/pdb
PDB entry 3fxk coloured by chain, front view.
PDB entry 3fxk coloured by chain, side view.
PDB entry 3fxk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Hu T, Wang L, Wang K, Jiang H, Shen X

Function and Biology Details

Reaction catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153029 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein phosphatase 1A Chain: A
Molecule details ›
Chain: A
Length: 390 amino acids
Theoretical weight: 43.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35813 (Residues: 1-382; Coverage: 100%)
Gene names: PPM1A, PPPM1A
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MN 2 x MN
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 90.76Å b: 90.76Å c: 105.711Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.196 0.234
Expression system: Escherichia coli

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