› 3g6d

X-ray diffraction
3.2Å resolution

Crystal structure of the complex between CNTO607 Fab and IL-13

Released:
DOI: 10.2210/pdb3g6d/pdb
PDB entry 3g6d coloured by chain, front view.
PDB entry 3g6d coloured by chain, side view.
PDB entry 3g6d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Epitope mapping of anti-interleukin-13 neutralizing antibody CNTO607.
Teplyakov A, Obmolova G, Wu SJ, Luo J, Kang J, O'Neil K, Gilliland GL
J Mol Biol 389 115-23 (2009)
PMID: 19361524

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211089 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
CNTO607 Fab Light chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 22.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
CNTO607 Fab Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 229 amino acids
Theoretical weight: 24.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Interleukin-13 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35225 (Residues: 35-146; Coverage: 92%)
Gene names: IL13, NC30
Sequence domains: Interleukin-13
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 66.54Å b: 68.03Å c: 182.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.263
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

2 review citations

Current approaches to fine mapping of antigen-antibody interactions.
Abbott et al. (2014)
1 more

11 mentions without citation

An overview of kinase downregulators and recent advances in discovery approaches.
Wang et al. (2021)
10 more