› › Structure analysis

Src Thr338Ile inhibited in the DFG-Asp-Out conformation

X-ray diffraction
2.35Å resolution
PDB entry 3g6h coloured by chain, front view.
PDB entry 3g6h coloured by chain, side view.
PDB entry 3g6h coloured by chain, top view.
Source organism: Gallus gallus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Proto-oncogene tyrosine-protein kinase Src
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Multimeric state: monomeric
Accessible surface area: 13602.51 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132629
Assembly 2 (preferred)
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Assembly Name: Proto-oncogene tyrosine-protein kinase Src
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Multimeric state: monomeric
Accessible surface area: 12920.47 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132629

Macromolecules

Proto-oncogene tyrosine-protein kinase Src
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.74 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Proto-oncogene tyrosine-protein kinase Src in PDB entry 3g6h, assembly 2, front view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 3g6h, assembly 2, side view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 3g6h, assembly 2, top view.
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