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SOLUTION NMR STRUCTURE OF THE GRB2 N-TERMINAL SH3 DOMAIN COMPLEXED WITH A TEN-RESIDUE PEPTIDE DERIVED FROM SOS DIRECT REFINEMENT AGAINST NOES, J-COUPLINGS, AND 1H AND 13C CHEMICAL SHIFTS, MINIMIZED AVERAGE STRUCTURE

Solution NMR
PDB entry 3gbq coloured by chain, front view.
PDB entry 3gbq coloured by chain, side view.
PDB entry 3gbq coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Son of sevenless homolog 1 and Growth factor receptor-bound protein 2
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Multimeric state: hetero dimer
Accessible surface area: 4931.64 Å2
Buried surface area: 1181.48 Å2
Dissociation area: 477.63 Å2
Dissociation energy (ΔGdiss): -1.12 kcal/mol
Dissociation entropy (TΔSdiss): 7.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-178798

Macromolecules

Growth factor receptor-bound protein 2
Chain: A
Length: 74 amino acids
Theoretical weight: 8.45 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q60631 (Residues: 1-61; Coverage: 28%)
Gene name: Grb2
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Growth factor receptor-bound protein 2 in PDB entry 3gbq, assembly 1, front view.
Growth factor receptor-bound protein 2 in PDB entry 3gbq, assembly 1, side view.
Growth factor receptor-bound protein 2 in PDB entry 3gbq, assembly 1, top view.
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Son of sevenless homolog 1
Chain: B
Length: 12 amino acids
Theoretical weight: 1.2 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q62245 (Residues: 1135-1144; Coverage: 1%)
Gene name: Sos1
Son of sevenless homolog 1 in PDB entry 3gbq, assembly 1, front view.
Son of sevenless homolog 1 in PDB entry 3gbq, assembly 1, side view.
Son of sevenless homolog 1 in PDB entry 3gbq, assembly 1, top view.
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