› 3gc8

X-ray diffraction
2.4Å resolution

The structure of p38beta C162S in complex with a dihydroquinazolinone

Released:
DOI: 10.2210/pdb3gc8/pdb
PDB entry 3gc8 coloured by chain, front view.
PDB entry 3gc8 coloured by chain, side view.
PDB entry 3gc8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.
Patel SB, Cameron PM, O'Keefe SJ, Frantz-Wattley B, Thompson J, O'Neill EA, Tennis T, Liu L, Becker JW, Scapin G
Acta Crystallogr D Biol Crystallogr 65 777-85 (2009)
PMID: 19622861

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 370 amino acids
Theoretical weight: 42.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15759 (Residues: 1-364; Coverage: 100%)
Gene names: MAPK11, PRKM11, SAPK2, SAPK2B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NA 2 x NA
Ligand B45 2 x B45
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 39.124Å b: 157.71Å c: 60.36Å
α: 90° β: 91.57° γ: 90°
R-values:
R R work R free
0.212 0.208 0.272
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Mechanisms and functions of p38 MAPK signalling.
Cuadrado et al. (2010)
4 more

12 mentions without citation

The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancer.
Acuner Ozbabacan et al. (2014)
11 more