› 3gni

X-ray diffraction
2.35Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181905 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calcium-binding protein 39 Chain: A
Molecule details ›
Chain: A
Length: 341 amino acids
Theoretical weight: 39.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y376 (Residues: 1-341; Coverage: 100%)
Gene names: CAB39, CGI-66, MO25
Sequence domains: Mo25-like
Structure domains: Leucine-rich Repeat Variant
STE20-related kinase adapter protein alpha Chain: B
Molecule details ›
Chain: B
Length: 389 amino acids
Theoretical weight: 43.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7RTN6 (Residues: 59-431; Coverage: 87%)
Gene names: LYK5, STRAD, STRADA
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CIT 1 x CIT
Ligand ATP 1 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 73.678Å b: 82.874Å c: 134.292Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.206 0.254
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Signalling scaffolds and local organization of cellular behaviour.
Langeberg et al. (2015)
26 more

12 mentions without citation

Pseudokinases-remnants of evolution or key allosteric regulators?
Zeqiraj et al. (2010)
11 more